I used to live and work on one of the main artery roads into my (smallish) town. It was just off an M25 junction and sometimes metal-to-metal. I never had any issues - there were a couple of handy side streets, and also my house wasn't directly overlooked by neighbours opposite. Plus, it was near a little parade of shops, so gave punters an excuse to be parked up there. As said, it's preferable to a very quiet street (or even worse, a cul-de-sac).