Mitigating risk is the name of the game.
Big hotels with night staff are generally much better than the smaller boutique hotels with no one on duty.
I love hotel outcalls as you can leave at your whim, but of course you have to do your safety checks as pertaining to the client themselves. Never ever slide into the comfort zone of thinking anyone or anywhere is safe.
If you have a gut instinct something is wrong when you arrive at the hotel, leave.
If you have a gut feeling something is wrong with the booking, call the hotel and ask for the guest in the room - any decent client would be okay with a woman doing this;
In general, I do find outcalls to hotels safe and I do prefer them over incalls to my apartment.